解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::LmrA is a bacterial ATP-binding cassette (ABC) multidrug exporter that uses metabolic energy to transport ions, cytotoxic drugs, and lipids. Voltage clamping in a Port-a-Patch was used to monitor electrical currents associated with the transport of monovalent cationic HEPES+ by single-LmrA transporters and ensembles o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aas9365
更新日期:2018-09-19 00:00:00
abstract::Half-filled Landau levels host an emergent Fermi liquid that displays instability toward pairing, culminating in a gapped even-denominator fractional quantum Hall ground state. While this pairing may be probed by tuning the polarization of carriers in competing orbital and spin degrees of freedom, sufficiently high qu...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat8742
更新日期:2018-09-14 00:00:00
abstract::Ants (Hymenoptera: Formicidae) are diverse and ubiquitous, and their ability to sting is familiar to many of us. However, their venoms remain largely unstudied. We provide the first comprehensive characterization of a polypeptidic ant venom, that of the giant red bull ant, Myrmecia gulosa. We reveal a suite of novel p...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aau4640
更新日期:2018-09-12 00:00:00
abstract::Crop diversification required to meet demands for food security and industrial use is often challenged by breeding time and amenability of varieties to genome modification. Cassava is one such crop. Grown for its large starch-rich storage roots, it serves as a staple food and a commodity in the multibillion-dollar sta...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat6086
更新日期:2018-09-05 00:00:00
abstract::Dynamic nuclear polarization (DNP) is an important technique that uses polarization transfer from electron to nuclear spins to achieve nuclear hyperpolarization. Combining efficient DNP with optically polarized nitrogen-vacancy (NV) centers offers promising opportunities for novel technological applications, including...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat8978
更新日期:2018-08-31 00:00:00
abstract::The Tulare Basin in Central California is a site of intensive agricultural activity and extraction of groundwater, with pronounced ground subsidence and degradation of water resources over the past century. Spatially extensive observations of ground displacements from satellite-based remote sensing allow us to infer t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aar8144
更新日期:2018-08-29 00:00:00
abstract::The established model-free methods for the processing of two-electron dipolar spectroscopy data [DEER (double electron-electron resonance), PELDOR (pulsed electron double resonance), DQ-EPR (double-quantum electron paramagnetic resonance), RIDME (relaxation-induced dipolar modulation enhancement), etc.] use regularize...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat5218
更新日期:2018-08-24 00:00:00
abstract::Like most homeostatic systems, adiposity in mammals is defended between upper and lower boundary conditions. While leptin and melanocortin-4 receptor (MC4R) signaling are required for defending energy set point, mechanisms controlling upper and lower homeostatic boundaries are less well understood. In contrast to the ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat0866
更新日期:2018-08-22 00:00:00
abstract::Rising sea levels will have overwhelmingly negative impacts on coastal communities globally. With previous research focused on how sea-level rise (SLR) affects storm-induced flooding, we show that SLR will also increase both the frequency and the intensity of tsunami-induced flooding, another significant coastal hazar...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat1180
更新日期:2018-08-15 00:00:00
abstract::G protein-coupled receptor 54 (GPR54), the key receptor for the neuropeptide hormone kisspeptin, plays essential roles in regulating puberty development and cancer metastasis. However, its role in the antiviral innate immune response is unknown. We report that virus-induced type I interferon (IFN-I) production was sig...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aas9784
更新日期:2018-08-08 00:00:00
abstract::Difunctionalization of alkenes is a valuable and versatile chemical transformation that could quickly build complex molecules. Extensive efforts have been made, and great achievement, such as Sharpless aminohydroxylation and dihydroxylation, has been reached. However, in marked contrast to the extensive research of am...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat5312
更新日期:2018-08-03 00:00:00
abstract::Complex behaviors demand temporal coordination among functionally distinct brain regions. The basal forebrain's afferent and efferent structure suggests a capacity for mediating this coordination at a large scale. During performance of a spatial orientation task, synaptic activity in this region was dominated by four ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aar3230
更新日期:2018-08-01 00:00:00
abstract::Previous studies have extensively investigated the impact of Arctic sea ice anomalies on the midlatitude circulation and associated surface climate in winter. However, there is an ongoing scientific debate regarding whether and how sea ice retreat results in the observed cold anomaly over the adjacent continents. We p...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat6025
更新日期:2018-07-25 00:00:00
abstract::The concept of repair is widely used by nature to heal molecules such as proteins, lipids, sugars, and DNA that are damaged by hydrogen atom abstraction resulting from oxidative stress. We show that this strategy, rather undocumented in the field of synthetic organic chemistry, can be used in a radical chain reaction ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat6031
更新日期:2018-07-20 00:00:00
abstract::We present a physically inspired model and an efficient algorithm to infer hierarchical rankings of nodes in directed networks. It assigns real-valued ranks to nodes rather than simply ordinal ranks, and it formalizes the assumption that interactions are more likely to occur between individuals with similar ranks. It ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aar8260
更新日期:2018-07-20 00:00:00
abstract::[This corrects the article DOI: 10.1126/sciadv.aao6652.]. ...
journal_title:Science advances
pub_type: 杂志文章,已发布勘误
doi:10.1126/sciadv.aau4932
更新日期:2018-07-13 00:00:00
abstract::The human transfer RNA methyltransferase 9-like gene (TRM9L, also known as KIAA1456) encodes a negative regulator of tumor growth that is frequently silenced in many forms of cancer. While TRM9L can inhibit tumor cell growth in vivo, the molecular mechanisms underlying the tumor inhibition activity of TRM9L are unknow...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aas9184
更新日期:2018-07-11 00:00:00
abstract::[This corrects the article DOI: 10.1126/sciadv.aar3761.]. ...
journal_title:Science advances
pub_type: 杂志文章,已发布勘误
doi:10.1126/sciadv.aau4713
更新日期:2018-07-06 00:00:00
abstract::Mineral exploitation has spread from land to shallow coastal waters and is now planned for the offshore, deep seabed. Large seafloor areas are being approved for exploration for seafloor mineral deposits, creating an urgent need for regional environmental management plans. Networks of areas where mining and mining imp...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aar4313
更新日期:2018-07-04 00:00:00
abstract::Metabolites of the intestinal microbiota are thought to be generated through metabolic pathways spanning multiple taxa of intestinal bacteria. We have previously shown that the level of putrescine, a polyamine found abundantly in the human intestinal lumen, is increased in the colonic lumen following administration of...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat0062
更新日期:2018-06-27 00:00:00
abstract::In the healthy kidney, specialized cells called podocytes form a sophisticated blood filtration apparatus that allows excretion of wastes and excess fluid from the blood while preventing loss of proteins such as albumin. To operate effectively, this filter is under substantial hydrostatic mechanical pressure. Given th...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aap8030
更新日期:2018-06-27 00:00:00
abstract::The inherent specificity and electrochemical reversibility of enzymes poise them as the biorecognition element of choice for a wide range of metabolites. To use enzymes efficiently in biosensors, the redox centers of the protein should have good electrical communication with the transducing electrode, which requires e...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat0911
更新日期:2018-06-22 00:00:00
abstract::Bioacoustic networks could vastly expand the coverage of wildlife monitoring to complement satellite observations of climate and vegetation. This approach would enable global-scale understanding of how climate change influences phenomena such as migratory timing of avian species. The enormous data sets that autonomous...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaq1084
更新日期:2018-06-20 00:00:00
abstract::Mimicking subcellular compartments containing enzymes in organisms is considered a promising approach to substitute for missing or lost cellular functions. Inspired by the multicompartment structures of cellular architectures, we present a novel multienzyme system based on hollow hydrogel microcapsules with flexible e...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat2816
更新日期:2018-06-15 00:00:00
abstract::Organic matter burial in mangrove forests results in the removal and long-term storage of atmospheric CO2, so-called "blue carbon." However, some of this organic matter is metabolized and returned to the atmosphere as CH4. Because CH4 has a higher global warming potential than the CO2 fixed in the organic matter, it c...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aao4985
更新日期:2018-06-13 00:00:00
abstract::Topological superconductors are an interesting and frontier topic in condensed matter physics. In the superconducting state, an order parameter will be established with the basic or subsidiary symmetry of the crystalline lattice. In doped Bi2Se3 or Bi2Te3 with a basic threefold symmetry, it was predicted, however, tha...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat1084
更新日期:2018-06-08 00:00:00
abstract::While the ecological impacts of fishing the waters beyond national jurisdiction (the "high seas") have been widely studied, the economic rationale is more difficult to ascertain because of scarce data on the costs and revenues of the fleets that fish there. Newly compiled satellite data and machine learning now allow ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat2504
更新日期:2018-06-06 00:00:00
abstract::We propose a method to use artificial neural networks to approximate light scattering by multilayer nanoparticles. We find that the network needs to be trained on only a small sampling of the data to approximate the simulation to high precision. Once the neural network is trained, it can simulate such optical processe...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aar4206
更新日期:2018-06-01 00:00:00
abstract::Precise protein folding is essential for the survival of all cells, and protein misfolding causes a number of diseases that lack effective therapies, yet the general principles governing protein folding in the cell remain poorly understood. In vivo, folding can begin cotranslationally and protein quality control at th...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aas9098
更新日期:2018-05-30 00:00:00
abstract::The accelerating global spread of arboviruses, such as Zika virus (ZIKV), highlights the need for more proactive mosquito surveillance. However, a major challenge during arbovirus outbreaks has been the lack of rapid and affordable tests for pathogen detection in mosquitoes. We show for the first time that near-infrar...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat0496
更新日期:2018-05-23 00:00:00
abstract::Stroke is the most common cause of adult disability in developed countries, largely because spontaneous recovery is often incomplete, and no pharmacological means to hasten the recovery exist. It was recently shown that mesencephalic astrocyte-derived neurotrophic factor (MANF) induces alternative or M2 activation of ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aap8957
更新日期:2018-05-23 00:00:00
abstract::In graphene superlattices, bulk topological currents can lead to long-range charge-neutral flow and nonlocal resistance near Dirac points. A ballistic version of these phenomena has never been explored. We report transport properties of ballistic graphene superlattices. This allows us to study and exploit giant nonloc...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaq0194
更新日期:2018-05-18 00:00:00
abstract::Previous identification of the inducible nitric oxide synthase (NOS2) gene as a risk allele for psoriasis (Ps) and psoriatic arthritis (PsA) suggests a possible pathogenic role of nitric oxide (NO). Using a mouse model of mannan-induced Ps and PsA (MIP), where macrophages play a regulatory role by releasing reactive o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aas9864
更新日期:2018-05-16 00:00:00
abstract::Quantum walks, in virtue of the coherent superposition and quantum interference, have exponential superiority over their classical counterpart in applications of quantum searching and quantum simulation. The quantum-enhanced power is highly related to the state space of quantum walks, which can be expanded by enlargin...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat3174
更新日期:2018-05-11 00:00:00
abstract::The mammalian retina system consists of a complicated photoreceptor structure, which exhibits extensive random synaptic connections. To study retinal development and degeneration, various experimental models have been used previously, but these models are often uncontrollable, are difficult to manipulate, and do not p...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aas9274
更新日期:2018-05-09 00:00:00
abstract::Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or "ωx") desatu...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aar6849
更新日期:2018-05-02 00:00:00
abstract::Ammonia synthesis consumes 3 to 5% of the world's natural gas, making it a significant contributor to greenhouse gas emissions. Strategies for synthesizing ammonia that are not dependent on the energy-intensive and methane-based Haber-Bosch process are critically important for reducing global energy consumption and mi...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.1700336
更新日期:2018-04-27 00:00:00
abstract::Predator-prey interactions revealed by vertebrate trace fossils are extremely rare. We present footprint evidence from White Sands National Monument in New Mexico for the association of sloth and human trackways. Geologically, the sloth and human trackways were made contemporaneously, and the sloth trackways show evid...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aar7621
更新日期:2018-04-25 00:00:00
abstract::The ability of a material to adopt multiple structures, known as polymorphism, is a fascinating natural phenomenon. Various polymorphs with unusual properties are routinely synthesized by compression under positive pressure. However, changing a material's structure by applying tension under negative pressure is much m...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaq1442
更新日期:2018-04-20 00:00:00
abstract::It has been proposed that Mars' moons formed from a disk produced by a large impact with the planet. However, whether such an event could produce tiny Phobos and Deimos remains unclear. Using a hybrid N-body model of moon accumulation that includes a full treatment of moon-moon dynamical interactions, we first identif...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aar6887
更新日期:2018-04-18 00:00:00